Computational Analysis of Single Nucleotide polymorphisms (SNPs) in Human TCell Acute Lymphocytic Leukemia Protein 1 (TAL1) Gene/Comprehensive Study
| Autor: | Afra A FadlAlla, Howina S Fadol, Fatima A. Abdelrhman, Alaa I. Abdalla, Mihad E. Elnnewery, Einas M. Yousif, Shaza W. Shantier, Hind K. Osman, Hashim E. Elmansi, Rawan A Elamin, Isam-Aldin A. Osman, Ahmed A Yagaub, Mohamed A. Hassan |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
T-Cell Acute Lymphocytic Leukemia Protein 1 In silico Lymphoblastic lymphoma Myeloid leukemia Single-nucleotide polymorphism Computational biology Protein structure function Biology medicine.disease 03 medical and health sciences 030104 developmental biology hemic and lymphatic diseases medicine Gene TAL1 |
| DOI: | 10.1101/447540 |
| Popis: | BackgroundTAL1is a proto-oncogene whose distorted modifications in committed T-cell Precursors is related with the development of T-ALL, it also found to be related to many other human hematological diseases such as lymphoblastic lymphoma, immunodeficiency 18, acute myeloid leukemia and diamond-blackfan Anemia.ObjectivesThis study aims to predict the effect of nsSNPs onTAL1protein structure functionMethodsRetrieved nSNPs in the coding and3’UTRregions were analyzed using different in silico tools. Interactions ofTAL1with functionally similar genes were investigated using Genemania. Post-translational modifications in several sites of the protein were also investigated.ResultsOut of ninety nsSNPs identified, only eight were found damaging to protein function of which one is located in the basis helix-loop-helix domain (bHLH). Two SNPs were anticipated by PolymiRTs to prompt disturbance or creation of miR binding sites.ConclusionThe present study is the first ever computational analysis ofTAL1’s nsSNPs hence this effort might be of help in the near future for inventing early diagnostic and therapeutic measures for T-ALL |
| Databáze: | OpenAIRE |
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