Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults
| Autor: | Keith A. Johnson, Colleen D. Fitzpatrick, Wai-Ying W Yau, Sherri Y Zhen, Rudolph E. Tanzi, Jasmeer P. Chhatwal, Becky C. Carlyle, Bianca A. Trombetta, Aaron P. Schultz, Dorene M. Rentz, Jeremy J. Pruzin, Steven E. Arnold, Can Zhang, Hyun-Sik Yang, Reisa A. Sperling, Dylan Kirn |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Epidemiology Amyloid beta medicine.medical_treatment tau Proteins medicine.disease_cause Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cognition Developmental Neuroscience Alzheimer Disease Internal medicine medicine Dementia Humans Cognitive Dysfunction Cognitive decline Aged Amyloid beta-Peptides biology business.industry Health Policy Neurodegeneration Immune dysregulation medicine.disease Interleukin-12 Psychiatry and Mental health 030104 developmental biology Endocrinology Cytokine Positron-Emission Tomography biology.protein Biomarker (medicine) Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Alzheimers Dement |
| Popis: | Introduction Immune dysregulation is implicated in neurodegeneration and altered cytokine levels are seen in people with dementia. However, whether cytokine levels are predictive of cognitive decline in cognitively unimpaired (CU) elderly, especially in the setting of elevated amyloid beta (Aβ), remains unclear. Methods We measured nine cytokines in the baseline plasma of 298 longitudinally followed CU elderly and assessed whether these measures were associated with cognitive decline, alone or synergistically with Aβ. We next examined associations between cytokine levels and neuroimaging biomarkers of Aβ/tau/neurodegeneration. Results Higher IL-12p70 was associated with slower cognitive decline in the setting of higher Aβ (false discovery rate [FDR] = 0.0023), whereas higher IFN-γ was associated with slower cognitive decline independent of Aβ (FDR = 0.013). Higher IL-12p70 was associated with less tau and neurodegeneration in participants with higher Aβ. Discussion Immune dysregulation is implicated in early-stage cognitive decline, and greater IL-12/IFN-γ axis activation may be protective against cognitive decline and early-stage AD progression. |
| Databáze: | OpenAIRE |
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