Estimation of expression of beta-human chorionic gonadotropin levels through progression of disease from normal to epithelial dysplasia to malignancy
| Autor: | Jyoti B Alur, Jaya Singh, Uma Swaminathan, P Sharada, Pritha Chowdhury, Ujjwal Mrinal |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Epithelial dysplasia
Pathology medicine.medical_specialty medicine.drug_class Beta-human chorionic gonadotropin medicine.disease_cause Malignancy Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine medicine 030212 general & internal medicine Stage (cooking) General Dentistry business.industry 030206 dentistry medicine.disease Epithelium oral squamous cell carcinoma stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Dysplasia immunohistochemical Immunohistochemistry Original Article Gonadotropin Carcinogenesis business |
| Zdroj: | Journal of Oral and Maxillofacial Pathology : JOMFP |
| ISSN: | 1998-393X 0973-029X |
| Popis: | Background: Gonadotropins have been extensively studied in trophoblastic and nontrophoblastic tumors of breast, gastric, bladder, parathyroid, renal cell and cervical carcinomas, with a significant increase in tissue expressions. Serum levels of beta-human chorionic gonadotropin (β-hCG) and its tissue expression were found more in oral squamous cell carcinoma (OSCC) patients with a significant diagnostic and prognostic value. No such study has been done on oral epithelial dysplasia (OED). Aims and Objective: To evaluate the expression of β-hCG in OED and the feasibility of using this marker for early diagnosis and to see its progression from normal to dysplasia to malignancy. Materials and Methods: The study population consisted of thirty histologically confirmed cases of OED and thirty cases of OSCC. Fifteen normal tissues were also included in the study. All the tissue samples were subjected to immunohistochemical (IHC) staining using antimouse β-hCG antibody. Results: The IHC expression of β-hCG was completely negative in normal cases (Group 1 [n = 15]), whereas 13 (43.3%) cases of OED (Group 2 [n = 30]) and 13 cases (43.3%) of OSCC (Group 3 [n = 30]) showed diffuse cytoplasmic staining in dysplastic surface epithelium and epithelial islands of OSCC. This difference was statistically significant with P = 0.007. Conclusion: We conclude that the expression of β-hCG increased from normal mucosa to dysplasia to OSCC, suggesting that it is involved in the early stage of carcinogenesis and progression of the disease. |
| Databáze: | OpenAIRE |
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