Does intraoperative application of leukocyte-poor platelet-rich plasma during arthroscopy for knee degeneration affect postoperative pain, function and quality of life? A 12-month randomized controlled double-blind trial
| Autor: | Georgios Spyrou, Matthias Lahner, T. Vogel, Christian Duif, Fatma Topcuoglu, Christoph von Schulze Pellengahr |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Degeneration (medical) Osteoarthritis law.invention Injections Intra-Articular Arthroscopy Intraoperative Period Quality of life Randomized controlled trial Double-Blind Method law medicine Humans Orthopedics and Sports Medicine Pain Measurement Knee arthroscopy medicine.diagnostic_test business.industry Platelet-Rich Plasma General Medicine Middle Aged Osteoarthritis Knee medicine.disease Surgery Pain Intractable Radiography Treatment Outcome Anesthesia Platelet-rich plasma Orthopedic surgery Quality of Life Female business |
| Zdroj: | Archives of orthopaedic and trauma surgery. 135(7) |
| ISSN: | 1434-3916 |
| Popis: | We aimed to identify the effects of intraoperative applied leukocyte-poor platelet-rich plasma (LP-PRP) during knee arthroscopy for degenerative lesions involving pain, function and quality of life.We performed a randomized controlled, double-blind trial (RCT) including 58 patients for arthroscopic knee surgery for cartilage or meniscal degeneration with allocation into the LP-PRP (n = 24) or control group (n = 34). During arthroscopy, LP-PRP was injected intra-articular in the intervention group. At baseline, 6 weeks, 6 months and 12 months pain, function, and life quality were assessed.91 % of enrolled patients were available for 12 months follow-up. Pain was significantly lower in the LP-PRP group (VAS 0.9. vs. 2.3) at 6 (p = 0.008) but not at 12 months (VAS 1.0 vs. 1.6, p = 0.063). LP-PRP application improved the Lysholm Score at 6 (77.5 vs. 65.6, p = 0.033) and 12 months (83.2 vs.70.0, p = 0.007). Assessment of life quality (SF-36) concerning the physical component summary was significantly higher at 6 weeks (33.9 vs. 25.6, p = 0.001) and 6 months (29.9 vs. 27.1, p = 0.027) in the LP-PRP group but equal at 1 year (31.4 vs. 30.1, p = 0.438).Intraoperative application of LP-PRP may enhance pain reduction and gain of knee function within 6-12 months compared to arthroscopy alone.II, randomized controlled clinical trial with reduced power. CLINICALTRIALS.NCT02189408. |
| Databáze: | OpenAIRE |
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