A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66
| Autor: | Jianhua Ju, Huayue Li, Huiming Huang, Yanhong Qiu, Wenli Li, Lukuan Hou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Magnetic Resonance Spectroscopy Stereochemistry Pharmaceutical Science Antineoplastic Agents Microbial Sensitivity Tests Gene Mutant Streptomyces somaliensis 01 natural sciences Streptomyces Mass Spectrometry 03 medical and health sciences Cell Line Tumor Drug Discovery Humans Dicarboxylic Acids Seawater Pharmacology Toxicology and Pharmaceutics (miscellaneous) Gene lcsh:QH301-705.5 Chromatography High Pressure Liquid Regulator gene Bacteria biology 010405 organic chemistry Cell growth Communication deepsea-derived Streptomyces biology.organism_classification dioic acid Anti-Bacterial Agents 0104 chemical sciences 030104 developmental biology lcsh:Biology (General) Cell culture Fermentation Mutation wblAso Drug Screening Assays Antitumor |
| Zdroj: | Marine Drugs, Vol 14, Iss 10, p 184 (2016) Marine Drugs |
| ISSN: | 1660-3397 |
| Popis: | The wblAso gene functions as a global regulatory gene in a negative manner in deepsea-derived Streptomyces somaliensis SCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the ΔwblAso mutant strain of S. somaliensis SCSIO ZH66. The structure of 1 was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound 3 exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC50 value of 19.4 μg/mL, while compounds 1 and 2 showed null activity up to 100 μg/mL. |
| Databáze: | OpenAIRE |
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