Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence
| Autor: | Ariane Rochat, Thimios A. Mitsiadis, Yann Barrandon, Hideo Oshima, Christèle Gonneau, Michael Nicolas, Jun-ichi Sakabe, Stéphanie Claudinot, Paola Bonfanti, Daniel Littman, Geert A. Martens |
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| Přispěvatelé: | University of Zurich, Claudinot, Stéphanie, Barrandon, Yann, Medical Biochemistry, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Endocrinology Diabetes and Metabolism epithelial stem cells cross lineages boundaries General Physics and Astronomy Mice 0302 clinical medicine embryonic epidermal cells Cornea Animals Epidermal Cells/metabolism Epidermis/growth & development Epidermis/metabolism Female Hair Follicle/metabolism Humans Rats Stem Cells/metabolism Trans-Activators/genetics Trans-Activators/metabolism lcsh:Science hair follicles p63 Multidisciplinary integumentary system Stem Cells p53 homolog 3100 General Physics and Astronomy Cell biology medicine.anatomical_structure Stem cell Hair Follicle human epidermis Science Morphogenesis morphogenesis 610 Medicine & health 1600 General Chemistry Genetics and Molecular Biology Biology Article General Biochemistry Genetics and Molecular Biology Tp63-expressing quality-control 03 medical and health sciences 1300 General Biochemistry Genetics and Molecular Biology expression Developmental biology medicine mouse Epidermis (botany) Regeneration (biology) Lineage markers Reprogramming ADULTS General Chemistry Hair follicle Embryonic stem cell basal-cells 10182 Institute of Oral Biology 030104 developmental biology Epidermal Cells regeneration General Biochemistry Trans-Activators identification lcsh:Q sense organs hairy skin Epidermis 030217 neurology & neurosurgery Skin stem cells |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020) Nature Communications Nature communications, vol. 11, no. 1, pp. 5645 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-19485-3 |
| Popis: | The formation of hair follicles, a landmark of mammals, requires complex mesenchymal–epithelial interactions and it is commonly believed that embryonic epidermal cells are the only cells that can respond to hair follicle morphogenetic signals in vivo. Here, we demonstrate that epithelial stem cells of non-skin origin (e.g. that of cornea, oesophagus, vagina, bladder, prostate) that express the transcription factor Tp63, a master gene for the development of epidermis and its appendages, can respond to skin morphogenetic signals. When exposed to a newborn skin microenvironment, these cells express hair-follicle lineage markers and contribute to hair follicles, sebaceous glands and/or epidermis renewal. Our results demonstrate that lineage restriction is not immutable and support the notion that all Tp63-expressing epithelial stem cells, independently of their embryonic origin, have latent skin competence explaining why aberrant hair follicles or sebaceous glands are sometimes observed in non-skin tissues (e.g. in cornea, vagina or thymus). Adult stem cells are thought to be fate restricted to lineages distinct to their tissue of origin. Here, the authors demonstrate that Tp63 expressing epithelial stem cells from several disparate tissues can respond to skin morphogenetic signals and contribute to hair follicles, sebaceous glands and/or epidermis. |
| Databáze: | OpenAIRE |
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