Catabolism of the Lipofuscin Cycloretinal by MsP1

Autor:	Irum Perveen, Brett A. Johnson, Vishruth Gowda, Brendan Foley, Stephanie Okezie, Mackenzie O’Brien, Coran M. H. Watanabe
Rok vydání:	2022
Předmět:	Kinetics Macular Degeneration Peroxidases Humans Biochemistry Chromatography High Pressure Liquid Lipofuscin
Zdroj:	Biochemistry. 61:2560-2567
ISSN:	1520-4995 0006-2960
DOI:	10.1021/acs.biochem.2c00413
Popis:	Age-related macular degeneration (AMD) is a debilitating eye disease that tends to affect people over the age of 55. Lipofuscins are autofluorescent, toxic byproducts of the visual cycle thought to contribute toward the progression of the disease. Targeting the accumulation of lipofuscin through catabolism may serve as a method for the early treatment of AMD. Thus, an enzymatic approach capable of degrading lipofuscin, cycloretinal (all
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425cab75664a6e48726214279ae6a908 https://doi.org/10.1021/acs.biochem.2c00413 Zobrazit plný text záznamu