Effect of α2-Adrenergic Receptor Stimulation on the Isolated Rat Heart against the Background of If Blockade
| Autor: | A. M. Kuptsova, M I Sungatullina, Timur Lvovich Zefirov, N. I. Ziyatdinova |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Agonist Tachycardia Inotrope medicine.medical_specialty medicine.drug_class Stimulation General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Heart Rate Receptors Adrenergic alpha-2 Internal medicine medicine Animals Coronary flow α2 adrenergic receptor Chemistry Myocardium Heart General Medicine Rat heart Rats Blockade Pyrimidines 030104 developmental biology Endocrinology medicine.symptom 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 169:635-638 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The study examined the effect of α2-adrenoreceptor (α2-AR) activation against the background of preliminary blockage of If on the performance of Langerndorff-isolated rat heart. Stimulation of α2-AR in isolated rat hearts against the background of ZD7288 in concentrations of 10-9 M and 3×10-5 M changed the negative dynamics of myocardial inotropy to positive (by 25 and 38%; p |
| Databáze: | OpenAIRE |
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