| Autor: |
Ensar Halilovic, Barbara Platzer, Jennifer Mataraza, Peter S. Hammerman, Juliet A. Williams, Claire Fabre, David A. Ruddy, Hao Wang, Yan Chen, Matthew D. Shirley, Roshani Patil, Nidhi Patel, Tyler A. Longmire, David S. Quinn, Gina Trabucco, Sema Kurtulus, Jinsheng Liang, Fiona Sharp, Iain J. Mulford, Hui Qin Wang |
| Rok vydání: |
2023 |
| DOI: |
10.1158/0008-5472.22429836.v1 |
| Popis: |
Supplementary information containing six supplementary figures (Figure S1-S6), one supplementary table (Table S1) and supplementary materials and methods. Supplementary Figure S1. Flow cytometric gating strategies for analysis of intra-tumoral T cells in parental and p53KO Colon26 tumors. Supplementary Figure S2. Flow cytometric gating strategies for analysis of intra-tumoral myeloid cells in parental and p53KO Colon26 tumors. Supplementary Figure S3. Anti-tumor activity of HDM201 in Colon26 syngeneic tumor model requires intact immune system. Supplementary Figure S4. p53 knockout in Colon 26 cells results in loss of response to HDM201 in vitro and in vivo. Supplementary Figure S5. HDM201 in combination with PD-1/PD-L1 blockade enhances anti-tumor responses in p53 wild-type tumors, but not in KO tumors. Supplementary Figure S6. Flow cytometric analysis of CD80, GITR, PD-L1, and CD86 expression after HDM201 treatment in vitro. Supplementary Table S1. Antibodies for flow cytometry analysis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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