| Autor: |
Thae Nu Htwe, Myat Mon Oo, Saw Wut Hmon, Moh Moh Htun, Ohnmar Myint Thein, Myat Thandar |
| Rok vydání: |
2015 |
| Předmět: |
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| DOI: |
10.5281/zenodo.3745901 |
| Popis: |
The insulin receptor substrate-1 gene (IRS-1) gene has been considered a candidate for insulin resistance in type-2 diabetes and coronary artery disease. The most common IRS-1 variant, a glycine to arginine change at codon 972(G972R) is more prevalent among subjects who have features of insulin resistance syndrome associated with type 2 diabetes patients. The aim of the present study was to determine the insulin receptor substrate-1 gene (G972R) polymorphism and insulin resistance in overweight and obese type 2 diabetes mellitus patients. The genomic DNA of the subjects was amplified by polymerase chain reaction (PCR) and digested by restriction fragment length polymorphism (RFLP) with BstN1 used for codon 972. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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