Evolutionary coupling between the deleteriousness of gene mutations and the amount of non-coding sequences

Autor: Carole Knibbe, Guillaume Beslon, Olivier Mazet, J.M. Fayard, Fabien Chaudier
Přispěvatelé: Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2), Biologie Fonctionnelle, Insectes et Interactions (BF2I), Institut National de la Recherche Agronomique (INRA)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon, Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA), Laboratoire Bf2i, Insa
Jazyk: angličtina
Rok vydání: 2007
Předmět:
0106 biological sciences
Statistics and Probability
Genome evolution
Genotype
Gene Expression
Biology
Gene mutation
010603 evolutionary biology
01 natural sciences
Genome
Gene dosage
Translocation
Genetic
General Biochemistry
Genetics and Molecular Biology
Genome Components
03 medical and health sciences
Gene Duplication
Animals
Gene
030304 developmental biology
Gene Rearrangement
Comparative genomics
Genetics
0303 health sciences
Models
Genetic
General Immunology and Microbiology
Applied Mathematics
Genetic Variation
Robustness (evolution)
[SDV.EE.IEO] Life Sciences [q-bio]/Ecology
environment/Symbiosis
General Medicine
Biological Evolution
Noncoding DNA
Phenotype
Modeling and Simulation
Mutation
1-1-1 Article périodique à comité de lecture
DNA
Intergenic
General Agricultural and Biological Sciences
Gene Deletion
[SDV.EE.IEO]Life Sciences [q-bio]/Ecology
environment/Symbiosis
Zdroj: Journal of Theoretical Biology
Journal of Theoretical Biology, Elsevier, 2007, 244 (4), pp.621-630
HAL
ISSN: 0022-5193
1095-8541
Popis: The phenotypic effects of random mutations depend on both the architecture of the genome and the gene-trait relationships. Both levels thus play a key role in the mutational variability of the phenotype, and hence in the long-term evolutionary success of the lineage. Here, by simulating the evolution of organisms with flexible genomes, we show that the need for an appropriate phenotypic variability induces a relationship between the deleteriousness of gene mutations and the quantity of non-coding sequences maintained in the genome. The more deleterious the gene mutations, the shorter the intergenic sequences. Indeed, in a shorter genome, fewer genes are affected by rearrangements (duplications, deletions, inversions, translocations) at each replication, which compensates for the higher impact of each gene mutation. This spontaneous adjustment of genome structure allows the organisms to retain the same average fitness loss per replication, despite the higher impact of single gene mutations. These results show how evolution can generate unexpected couplings between distinct organization levels.
Databáze: OpenAIRE
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