Relationship between progression of gastric mucosal atrophy andHelicobacter pylori infection: Retrospective long-term endoscopic follow-up study

Autor: Chikara Ishikawa, Yoshiya Yamada, Takeo Arakawa, Hiroaki Katou, Nobuhiro Sakaki, Jun-ichi Ishiwata, Kumiko Momma, Yuyang Tu, Naoto Egawa, Terumi Kamisawa
Rok vydání: 1997
Předmět:
Zdroj: Journal of Gastroenterology. 32:19-23
ISSN: 1435-5922
0944-1174
DOI: 10.1007/bf01213291
Popis: A retrospective long-term endoscopic follow-up study was designed to examine atrophic changes in the gastric mucosa over time in Helicobacter pylori-positive patients. Over a period of 8-17 years (mean, 13.4 years) 22 subjects (5 men, 17 women, mean age, 55 years) without localized gastroduodenal lesions underwent serial endoscopic examinations and serological and microbiological assessments of H. pylori infection. The extent of atrophic mucosa in the gastric body was expressed using the Kimura-Takemoto classification of atrophic pattern. Atrophic patterns were unchanged over time in 7 H. pylori-seronegative and culture-negative subjects with normal stomach, and in 1 seropositive and culture-negative subject with severe atrophy. Seven of 10 H. pylori culture-positive subjects not including three with the O-3 pattern, i.e., open type atrophic pattern, exhibited a cephalad shift of atrophic pattern. The cumulative progression rates of atrophy in the culture-positive subjects excluding O-3 subjects, were 10% after 2 years, 20% after 4 years, 50% after 6 years, and 70% after 8 years. The increases in the extent of the atrophic area were discontinuous, in terms of age, in the H. pylori-positive individuals and occasionally advanced rapidly within periods of several years with no relation to age.
Databáze: OpenAIRE
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