Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

Autor:	Yi-Hui Peng, Fang-Yu Liao, Chen-Tso Tseng, Ramajayam Kuppusamy, An-Siou Li, Chi-Han Chen, Yu-Shiou Fan, Sing-Yi Wang, Mine-Hsine Wu, Ching-Cheng Hsueh, Jia-Yu Chang, Lung-Chun Lee, Chuan Shih, Kak-Shan Shia, Teng-Kuang Yeh, Ming-Shiu Hung, Ching-Chuan Kuo, Jen-Shin Song, Su-Ying Wu, Shau-Hua Ueng
Rok vydání:	2020
Předmět:	Structure-Activity Relationship Thiazoles Binding Sites Molecular Structure Drug Discovery Imidazoles Humans Indoleamine-Pyrrole 2 3 -Dioxygenase Molecular Medicine Enzyme Inhibitors Crystallography X-Ray Protein Binding
Zdroj:	Journal of Medicinal Chemistry. 63:1642-1659
ISSN:	1520-4804 0022-2623
Popis:	Indoleamine 2,3-dioxygenase (IDO1) inhibitors are speculated to be useful in cancer immunotherapy, but a phase III clinical trial of the most advanced IDO1 inhibitor, epacadostat, did not meet its primary end point and was abandoned. In previous work, we identified the novel IDO1 inhibitor
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4258e7674e4456ad315cdaea64c49e02 https://doi.org/10.1021/acs.jmedchem.9b01549 Zobrazit plný text záznamu