Antimicrobial Effects of Chemically Functionalized and/or Photo-Heated Nanoparticles
| Autor: | Luciano De Sio, Ferdinanda Annesi, Luigia Pezzi, Alexa Guglielmelli, Maria Adele Losso, Alfredo Pane, Cesare Umeton |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
antibiotic resistance Nanoparticle Nanotechnology antibacterial agents 02 engineering and technology 010402 general chemistry gold nanoparticles plasmonic resonance thermal inactivation 01 natural sciences lcsh:Technology Nanomaterials Antibiotic free General Materials Science Metal nanoparticles lcsh:Microscopy lcsh:QC120-168.85 lcsh:QH201-278.5 lcsh:T 021001 nanoscience & nanotechnology Antimicrobial 0104 chemical sciences Colloidal gold lcsh:TA1-2040 Perspective Titanium dioxide nanoparticles Temperature sensitive lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering 0210 nano-technology lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 |
| Zdroj: | Materials, Vol 12, Iss 7, p 1078 (2019) Materials |
| ISSN: | 1996-1944 |
| Popis: | Antibiotic resistance refers to when microorganisms survive and grow in the presence of specific antibiotics, a phenomenon mainly related to the indiscriminate widespread use and abuse of antibiotics. In this framework, thanks to the design and fabrication of original functional nanomaterials, nanotechnology offers a powerful weapon against several diseases such as cancer and pathogenic illness. Smart nanomaterials, such as metallic nanoparticles and semiconductor nanocrystals, enable the realization of novel drug-free medical therapies for fighting against antibiotic-resistant bacteria. In the light of the latest developments, we highlight the outstanding capabilities of several nanotechnology-inspired approaches to kill antibiotic-resistant bacteria. Chemically functionalized silver and titanium dioxide nanoparticles have been employed for their intrinsic toxicity, which enables them to exhibit an antimicrobial activity while, in a different approach, photo-thermal properties of metallic nanoparticles have been theoretically studied and experimentally tested against several temperature sensitive (mesophilic) bacteria. We also show that it is possible to combine a highly localized targeting with a plasmonic-based heating therapy by properly functionalizing nanoparticle surfaces with covalently linked antibodies. As a perspective, the utilization of properly engineered and chemically functionalized nanomaterials opens a new roads for realizing antibiotic free treatments against pathogens and related diseases. |
| Databáze: | OpenAIRE |
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