Markedly improved skeletal muscle function with local muscle training in patients with chronic heart failure
| Autor: | Raija Tyni-Lenné, Allan Gordon, Christer Sylvén, H Persson, L. Kaijser, E Hultman |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Strength training Cardiac Output Low Physical exercise Citrate (si)-Synthase Oxygen Consumption Deconditioning Endurance training Internal medicine medicine Humans Muscle Skeletal Aged business.industry Skeletal muscle VO2 max General Medicine Middle Aged medicine.disease Adaptation Physiological Quadriceps femoris muscle Exercise Therapy medicine.anatomical_structure Heart failure Physical therapy Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Clinical Cardiology. 19:568-574 |
| ISSN: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.4960190709 |
| Popis: | Background: Reduced heart pump function and skeletal muscle abnormalities are considered important determinants for the low physical exercise capacity in chronic heart failure. Because of reduced ventricular function, traditional physical rehabilitation may cause underperfusion and low local work intensity, thereby producing suboptimal conditions for skeletal muscle training. Hypothesis: The study was undertaken to determine the effects of local exercise training, designed as one- or two-legged knee extensor training, on exercise capacity in patients with moderate chronic heart failure. Because such exercise models use only about one quarter to half the muscle mass used in cycle ergometer training, the influence of a restricted circulatory capacity should therefore be limited. Further, we aimed to determine whether or not chronic heart failure skeletal musculature abnormalities are counteracted with such training. Methods: Fourteen patients with chronic heart failure [age 58 ± 3 years, ejection fraction (EF) 28 ±4%] were randomized to two different training protocols three times a week for 8 weeks and compared with a nontraining control group (n = 7, age 62 ± 3, EF 27 ± 3%). Group 2L (n = 7) underwent simultaneous two-legged knee extensor training (about 4 kg working muscle) for 15 min at 65–75% of VO2 max of the two-legged kick. Group 1L (n = 7) trained each leg at a time for 15 min of continuous one-legged dynamic knee extensor work with the same training load per muscle mass, that is, at 35% of VO2 max of the two-legged kick (about 2 kg working muscle). Peak VO2 of two-legged knee extensor exercise (1/min), two-legged endurance (W), and strength (Nm) were determined before and after the training period. The activity of citrate syn-thase (CS) was estimated in tissue samples from the quadriceps femoris muscle. Results: Peak VO2 did not change with training. Two-legged knee extensor endurance exercise capacity increased by an average of 40–50% (p |
| Databáze: | OpenAIRE |
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