High Levels of Hyaluronic Acid Synthase-2 Mediate NRF2-Driven Chemoresistance in Breast Cancer Cells

Autor:	Bo-Hyun, Choi, Ingeun, Ryoo, Kyeong Hwa, Sim, Hyeon-Jin, Ahn, Youn Ju, Lee, Mi-Kyoung, Kwak
Rok vydání:	2022
Předmět:	Pharmacology Drug Discovery Molecular Medicine Biochemistry
Zdroj:	Biomolecules & Therapeutics. 30:368-379
ISSN:	2005-4483 1976-9148
DOI:	10.4062/biomolther.2022.074
Popis:	Hyaluronic acid (HA), a ligand of CD44, accumulates in some types of tumors and is responsible for tumor progression. The nuclear factor erythroid 2-like 2 (NRF2) regulates cytoprotective genes and drug transporters, which promotes therapy resistance in tumors. Previously, we showed that high levels of CD44 are associated with NRF2 activation in cancer stem like-cells. Herein, we demonstrate that HA production was increased in doxorubicin-resistant breast cancer MCF7 cells (MCF7-DR) via the upregulation of HA synthase-2 (HAS2). HA incubation increased NRF2, aldo-keto reductase 1C1 (AKR1C1), and multidrug resistance gene 1 (MDR1) levels. Silencing of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4253c3f8a0c5ad529bb0bb4fdaf8907d https://doi.org/10.4062/biomolther.2022.074 Zobrazit plný text záznamu