Metabolic syndrome is common among middle-to-older aged Mediterranean patients with rheumatoid arthritis and correlates with disease activity: a retrospective, cross-sectional, controlled, study
| Autor: | G. Bertsias, Prodromos Sidiropoulos, Stylianos A Karvounaris, Emmanuel S. Ganotakis, John A. Papadakis, Dimitrios T. Boumpas, Elias K. Spanakis, Herakles Kritikos |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Risk musculoskeletal diseases medicine.medical_specialty Cross-sectional study Immunology Disease General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Rheumatology Internal medicine Prevalence medicine Health Status Indicators Humans Immunology and Allergy skin and connective tissue diseases Aged Retrospective Studies Metabolic Syndrome Chi-Square Distribution Greece business.industry Case-control study Retrospective cohort study Middle Aged medicine.disease Connective tissue disease Extended Report Cross-Sectional Studies Logistic Models Case-Control Studies Rheumatoid arthritis Cohort Physical therapy Female Joints Metabolic syndrome business |
| Zdroj: | Annals of the Rheumatic Diseases. 66:28-33 |
| ISSN: | 0003-4967 |
| DOI: | 10.1136/ard.2006.053488 |
| Popis: | Objectives: Patients with rheumatoid arthritis have an increased risk for cardiovascular disease (CVD). The prevalence of metabolic syndrome (MetS)—a major contributor to CVD—in a cohort of patients with rheumatoid arthritis and its relationship with rheumatoid arthritis related factors is investigated here. Methods: 200 outpatients with rheumatoid arthritis (147 women and 53 men), with a mean (standard deviation (SD)) age of 63 (11) years, and 400 age and sex-matched controls were studied. MetS was assessed according to the adult treatment panel III criteria and rheumatoid arthritis disease activity by the disease activity score of 28 joints (DAS28). A standard clinical evaluation was carried out, and a health and lifestyle questionnaire was completed. Results: The overall prevalence of MetS was 44% in patients with rheumatoid arthritis and 41% in controls (p = 0.5). Patients with rheumatoid arthritis were more likely to have low high-density lipoprotein cholesterol compared with controls (p = 0.02), whereas controls were more likely to have increased waist circumference or raised blood pressure (p = 0.001 and 0.003, respectively). In multivariate logistic regression analysis adjusting for demographics and rheumatoid arthritis treatment modalities, the risk of having moderate-to-high disease activity (DAS28>3.2) was significantly higher in patients with MetS compared with those with no MetS components (OR 9.24, 95% CI 1.49 to 57.2, p = 0.016). Conclusion: A high, albeit comparable to the control population, prevalence of MetS was found in middle-to-older aged patients with rheumatoid arthritis. The correlation of rheumatoid arthritis disease activity with MetS suggests that the increased prevalence of coronary heart disease in patients with rheumatoid arthritis may, at least in part, be attributed to the inflammatory burden of the disease. |
| Databáze: | OpenAIRE |
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