Encapsulation of vitamin B-12 into nanoengineered capsules and soft matter nanosystems for targeted delivery
| Autor: | O. A. Gromova, Oscar I. Koifman, Michela Pisani, Victor Erokhin, Massimo Marcaccio, Larissa A. Maiorova, Svetlana Erokhina, Gianni Barucca, Denis S. Salnikov, Paola Astolfi, Valentina Ricci |
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| Přispěvatelé: | Maiorova L.A., Erokhina S.I., Pisani M., Barucca G., Marcaccio M., Koifman O.I., Salnikov D.S., Gromova O.A., Astolfi P., Ricci V., Erokhin V. |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Vitamin
Materials science Vitamin B-12 Nanoengineered polymer capsule Nanotechnology 02 engineering and technology Cubosomes 01 natural sciences chemistry.chemical_compound Colloid and Surface Chemistry Self-assembled nanostructures 0103 physical sciences Amphiphile Lyotropic Vitamin B12 Soft matter Physical and Theoretical Chemistry Vitamin B chemistry.chemical_classification Nanoengineered polymer capsules 010304 chemical physics Small-angle X-ray scattering Self-assembled nanostructure Surfaces and Interfaces General Medicine Polymer SAXS 021001 nanoscience & nanotechnology chemistry Transmission electron microscopy Cubosome Targeted delivery 0210 nano-technology Biotechnology |
| Zdroj: | Colloids and surfaces. B, Biointerfaces 182 (2019): 110366-1. doi:10.1016/j.colsurfb.2019.110366 info:cnr-pdr/source/autori:Maiorova, Larissa A.; Erokhina, Svetlana, I; Pisani, Michela; Barucca, Gianni; Marcaccio, Massimo; Koifman, Oscar, I; Salnikov, Denis S.; Gromova, Olga A.; Astolfi, Paola; Ricci, Valentina; Erokhin, Victor/titolo:Encapsulation of vitamin B-12 into nanoengineered capsules and soft matter nanosystems for targeted delivery/doi:10.1016%2Fj.colsurfb.2019.110366/rivista:Colloids and surfaces. B, Biointerfaces (Print)/anno:2019/pagina_da:110366-1/pagina_a:/intervallo_pagine:110366-1/volume:182 |
| DOI: | 10.1016/j.colsurfb.2019.110366 |
| Popis: | Targeted delivery of vitamins to a desirable area is an active branch in a modern pharmacology. The most important and difficult delivery of vitamin B12 is that to bone marrow and nerve cells. Herein we present a first step towards the development of two types of smart carriers, polymer capsules and lyotropic liquid-crystalline nanosystems, for vitamin B12 targeted delivery and induced release. A vitamin B12 encapsulation technique into nanoengineered polymeric capsules produced by layer-by-layer assembling of polymeric shells on CaCO3 templates has been developed. The effectiveness of the process was demonstrated by optical absorption spectroscopy, transmission electron microscopy (TEM), atomic force microscopy (AFM) and small-angle X-ray diffraction. TEM and AFM analyses performed on capsules after their drying, confirmed the presence of the vitamin B12 inside the capsules in the form of crystalline nanoaggregates, 50–300 nm in diameter. Soft lipid nanovectors consisting of amphiphilic phytantriol molecules, which in water excess spontaneously self-assembly in 3D well-ordered inverse bicontinuous cubic bulk phase, were used as alternative carriers for vitamin B12. It was shown that about 30% of the vitamin added in the preparation of the soft lipid system was actually encapsulated in cubosomes and that no structural changes occurred upon loading. The Vitamin stabilizes the lipid system playing the role of its structure-forming element. The biocompatible nature, the stability and the feasibility of these systems make them good candidates as carriers for hydrophilic vitamins. |
| Databáze: | OpenAIRE |
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