Detection of experimental atherosclerosis with indium-111 radiolabelled hematoporphyrin derivative
| Autor: | Turner Fe, Robert T. Palac, Malinow Mr, Gray Ll, Paul H. Brown, H. Demots |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Aortic arch Experimental atherosclerosis medicine.medical_specialty Arteriosclerosis Aorta Thoracic Derivative Cholesterol Dietary chemistry.chemical_compound Internal medicine medicine.artery medicine Animals Radiology Nuclear Medicine and imaging Radionuclide Imaging Photofrin II Hematoporphyrin Cholesterol Indium Radioisotopes General Medicine Disease Models Animal Hematoporphyrins Endocrinology chemistry Dihematoporphyrin Ether Female Rabbits WHOLE ANIMAL Whole body |
| Zdroj: | Nuclear Medicine Communications. 10:841-850 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-198911000-00009 |
| Popis: | It has been observed that atherosclerotic lesions (AL) concentrate certain porphyrins. We evaluated the usefulness of 111In-labelled Photofrin II (PFII), a porphyrin derived from haematoporphyrin derivative, for detection of experimental AL in cholesterol fed rabbits. Three groups of rabbits were studied: non-atherosclerotic (n = 3), 6 and 12 week cholesterol fed (n = 4, 3). 111In-PFII was injected intravenously and gamma camera images were obtained at 24 and 48 h. At 48 h, explanted aortas were also imaged. Aortic arch (AA) to background (BKG) count ratios were calculated from images of the whole body and explanted aortas. AA/BKG ratios were significantly higher in the 12 week cholesterol fed rabbits (3.9 +/- 0.72 at 24 h) and (4.0 +/- 0.67 at 48 h) than in the non-atherosclerotic rabbits (2.2 +/- 0.07 at 24 h) and (2.3 +/- 0.18 at 48 h) (p less than 0.05). The AA/BKG ratio for the explanted aortas showed similar results. Additionally, in two of three 12 week cholesterol fed rabbits, focal count deposition was visible on the whole animal images at the site of aortic arch atherosclerosis. We conclude that 111In-PFII concentrates in AL as early as 24 h after injection and has the potential to be used as an imaging agent for experimental atherosclerosis. |
| Databáze: | OpenAIRE |
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