A new formula for estimation of low-density lipoprotein cholesterol in an ethnic Chinese population
| Autor: | Jiin-Tsae Ling, Yuh-Min Song, Chia Lin Lee, Wayne Huey-Herng Sheu, Yu-Fen Li, Chia-Po Fu, Ching-Yun Hu, Jun-Sing Wang, Shih-Yi Lin, I-Te Lee |
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| Rok vydání: | 2015 |
| Předmět: |
Male
China medicine.medical_specialty Clinical Biochemistry Population Low density lipoprotein cholesterol chemistry.chemical_compound Asian People Total cholesterol Internal medicine Linear regression Ethnicity medicine Humans education education.field_of_study Triglyceride Chemistry Cholesterol Biochemistry (medical) Ethnic chinese Cholesterol LDL General Medicine Middle Aged Cross-Sectional Studies Endocrinology Linear Models Female Lipid lowering |
| Zdroj: | Clinical Chemistry and Laboratory Medicine (CCLM). 53 |
| ISSN: | 1437-4331 1434-6621 |
| DOI: | 10.1515/cclm-2014-1029 |
| Popis: | Low-density lipoprotein cholesterol (LDL-C) is an established risk factor for cardiovascular disease and is usually estimated by the Friedewald formula (FF) calculated from three parameters, namely, total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C). We aimed to develop a new and simple formula (NF) for LDL-C estimation.This cross-sectional study enrolled two study populations (a testing group, n=16,749, and a validation group, n=4940). Linear regression analysis was used in the testing group to investigate the association between measured LDL-C (mLDL-C) and TC concentration, and was verified in the validation group.The NF yielded an estimated LDL-C (eLDL-C) equal to 0.75×total cholesterol–0.6465 (mmol/L). For the subjects with TC between 2.58 and 7.74 mmol/L, the difference between mLDL-C and eLDL-C using the NF was less than that from the FF (testing group: –0.04 to –0.20 vs. –0.28 to –0.38 mmol/L; validation group: 0.01 to –0.12 vs. –0.23 to –0.30 mmol/L; p7.74 mmol/L, respectively.In the Chinese population, the accuracy of eLDL-C measurement with the NF was better than that with the FF, especially in subjects with TC levels between 2.58 and 7.74 mmol/L. The NF is simple and may be used for screening as well as for follow-up of patients on lipid lowering agents. |
| Databáze: | OpenAIRE |
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