Molybdopterin biosynthesis—Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP
| Autor: | Angad P. Mehta, Sameh H. Abdelwahed, Tadhg P. Begley |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Purine
GTP' Stereochemistry Ribose Coenzymes Biophysics Substrate analog Biochemistry Article Analytical Chemistry Catalysis chemistry.chemical_compound Biosynthesis Metalloproteins Humans Moiety Isomerases Molecular Biology Escherichia coli Proteins Pteridines Molybdopterin Carbon chemistry Purines Biocatalysis Guanosine Triphosphate Molybdenum Cofactors |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1854:1073-1077 |
| ISSN: | 1570-9639 |
| DOI: | 10.1016/j.bbapap.2015.04.008 |
| Popis: | The first step in the biosynthesis of the molybdopterin cofactor involves an unprecedented insertion of the purine C8 carbon between the C2' and C3' carbons of the ribose moiety of GTP. Here we review mechanistic studies on this remarkable transformation. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications. |
| Databáze: | OpenAIRE |
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