Outcome of preimplantation genetic diagnosis using FISH analysis for recurrent miscarriage in low-risk reciprocal translocation carriers
| Autor: | Laurice Magdalani, Tarek El-Toukhy, Jyotsna Pundir |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Abortion Habitual Pregnancy Rate Offspring Chromosomal translocation Preimplantation genetic diagnosis Translocation Genetic Miscarriage Andrology 03 medical and health sciences 0302 clinical medicine Pregnancy Recurrent miscarriage medicine Humans Genetic Testing Birth Rate In Situ Hybridization Fluorescence Preimplantation Diagnosis Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Pregnancy Outcome Obstetrics and Gynecology Embryo Transfer medicine.disease Embryo transfer 030104 developmental biology Reproductive Medicine Female Live birth business Live Birth |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 203:214-219 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2016.05.053 |
| Popis: | Objective To assess PGD outcome using FISH analysis in couples with a history of recurrent miscarriage associated with a parental carrier of reciprocal translocation. Study design Couples in whom one partner was a carrier of a reciprocal translocation and had a history of two or more miscarriages and a low risk of a live born offspring with an unbalanced chromosomal rearrangement, underwent PGD treatment between 2000 and 2012. Results 91 couples started 171 fresh and 11 frozen PGD cycles. Of the fresh cycles, 162 (95%) reached oocyte retrieval and 107 (63%) had embryo transfer. In 14 cycles (8%), surplus embryos were cryopreserved. Pregnancy was achieved in 52 fresh PGD cycles, leading to 20 miscarriages and 32 live births. Eleven frozen embryo transfer cycles resulted in two miscarriages and three live births. The overall live birth rate was 19% per fresh and frozen PGD cycle started (35/182) and miscarriage rate was 39% per pregnancy (22/57). The cumulative live birth rate was 32% per couple (29/91). Conclusion After PGD for recurrent miscarriage in low-risk reciprocal translocation carriers, the miscarriage risk remains high and chance of live birth is low. For those translocation carriers, natural conception may be a better option. |
| Databáze: | OpenAIRE |
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