The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress
| Autor: | Ester Méndez, Manuel Mendoza, Mercè Gomar-Alba, J. Carlos Igual, M. Carmen Bañó, Inma Quilis |
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| Přispěvatelé: | Universitat de València (UV), Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Mendoza, Manuel, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Saccharomyces cerevisiae Proteins
Cell division [SDV]Life Sciences [q-bio] Repressor Saccharomyces cerevisiae Biology Cell cycle Cicle cel·lular Stress 03 medical and health sciences 0302 clinical medicine Whi7 Gene Expression Regulation Fungal medicine Whi5 030304 developmental biology 0303 health sciences Retinoblastoma Cèl·lules eucariotes Promoter Cell Biology Subcellular localization medicine.disease Start Budding yeast Cell biology Repressor Proteins Decision points [SDV] Life Sciences [q-bio] Saccharomycetales Cell Division 030217 neurology & neurosurgery Research Article |
| Zdroj: | Journal of Cell Science Journal of Cell Science, Company of Biologists, 2020, 133 (24), ⟨10.1242/jcs.251413⟩ Journal of Cell Science, 2020, 133 (24), ⟨10.1242/jcs.251413⟩ Méndez Belinchón, Ester Gomar Alba, Mercè Bañó Aracil, María del Carmen Mendoza, Manuel Quilis Bayarri, Inmaculada Igual García, Juan Carlos 2020 The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress Journal of Cell Science 133 24 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname RODERIC: Repositorio Institucional de la Universitat de Valéncia article-version (VoR) Version of Record |
| ISSN: | 0021-9533 1477-9137 |
| DOI: | 10.1242/jcs.251413⟩ |
| Popis: | Start is the main decision point in the eukaryotic cell cycle at which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional programme through the inactivation of Start transcriptional repressors: the retinoblastoma family in mammals, or Whi5 and its recently identified paralogue Whi7 (also known as Srl3) in budding yeast. Here, we provide a comprehensive comparison of Whi5 and Whi7 that reveals significant qualitative differences. Indeed, the expression, subcellular localization and functionality of Whi7 and Whi5 are differentially regulated. Importantly, Whi7 shows specific properties in its association with promoters not shared by Whi5, and for the first time, we demonstrate that Whi7, and not Whi5, can be the main contributor to Start inhibition such as it occurs in the response to cell wall stress. Our results help to improve understanding of the interplay between multiple differentially regulated Start repressors in order to face specific cellular conditions. Highlighted Article: Cells can use the interplay between functionally redundant but differentially regulated cell-cycle repressors in order to confer new repression capabilities and to respond to specific cellular conditions. |
| Databáze: | OpenAIRE |
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