Hematopoietic stem/progenitor involvement in retinal microvascular repair during diabetes: Implications for bone marrow rejuvenation
| Autor: | Ping Hu, Lynn C Shaw, Ashay D. Bhatwadekar, Sameer P. Leley, Sergio Caballero, Maria Korah, Maria B. Grant, Yaqian Duan, Jeffrey S. Thinschmidt, Julia V. Busik |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Population Article 03 medical and health sciences chemistry.chemical_compound Bone Marrow Diabetes mellitus medicine Humans Rejuvenation Progenitor cell Stem Cell Niche education Progenitor education.field_of_study Diabetic Retinopathy business.industry Retinal Vessels Diabetic retinopathy medicine.disease Hematopoietic Stem Cells Sensory Systems Ophthalmology Haematopoiesis 030104 developmental biology medicine.anatomical_structure chemistry Cancer research Advanced glycation end-product Bone marrow business |
| Zdroj: | Vision research. 139 |
| ISSN: | 1878-5646 |
| Popis: | The widespread nature of diabetes affects all organ systems of an individual including the bone marrow. Long-term damage to the cellular and extracellular components of the bone marrow leads to a rapid decline in the bone marrow-hematopoietic stem/progenitor cells (HS/PCs) compartment. This review will highlight the importance of bone marrow microenvironment in maintaining bone marrow HS/PC populations and the contribution of these key populations in microvascular repair during the natural history of diabetes. The autonomic nervous system can initiate and propagate bone marrow dysfunction in diabetes. Systemic pharmacological strategies designed to protect the bone marrow-HS/PC population from diabetes induced-oxidative stress and advanced glycation end product accumulation represent a new approach to target diabetic retinopathy progression. Protecting HS/PCs ensures their participation in vascular repair and reduces the risk of vasogdegeneration occurring in the retina. |
| Databáze: | OpenAIRE |
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