Nonfunctional overreaching and hepatic adaptations of APPL1 and APPL2
| Autor: | José Rodrigo Pauli, Larissa G. de Vicente, Luciana da C Oliveira, Gustavo P. Morais, Bruno Pereira, Ana P. Pinto, Adelino Sanchez Ramos da Silva, Alisson L. da Rocha |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Downhill running medicine.medical_specialty Health (social science) overtraining protocols insulin pathway glucose homeostasis Significant elevation lcsh:GV557-1198.995 03 medical and health sciences chemistry.chemical_compound Downregulation and upregulation Internal medicine medicine GLICOSE Glucose homeostasis APPL1 lcsh:Sports medicine Protein kinase B lcsh:Sports Glycogen business.industry Overtraining General Medicine Overreaching medicine.disease 030104 developmental biology Endocrinology chemistry lcsh:RC1200-1245 business |
| Zdroj: | Motriz: Revista de Educação Física, Volume: 23, Issue: spe, Article number: e101611, Published: 02 MAY 2017 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Motriz: Revista de Educacao Fisica, Vol 23, Iss spe (2017) Motriz: Revista de Educação Física v.23 n.spe 2017 Motriz Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1980-6574 |
| DOI: | 10.1590/s1980-6574201700si0014 |
| Popis: | AIMS Previously, we verified that overtrained mice upregulated the TRB3 levels, its association with Akt, and the hepatic concentrations of glycogen. It is known that APPL1 can limit the interaction between TRB3 and Akt, playing an important role in the glucose homeostasis. Thus, we verified the effects of three overtraining protocols on the hepatic levels of APPL1 and APPL2. METHODS Rodents were divided into control (CT), overtrained by downhill running (OTR/down), overtrained by uphill running (OTR/up) and overtrained by running without inclination (OTR). The hepatic contents of APPL1 and APPl2 were measured by the immunoblotting technique. RESULTS Significant elevation of APPL1 observed in the OTR/down and OTR/up groups, as well as the tendency of increase (p=0.071) observed in the OTR group. CONCLUSION These results indicate that this particular protein is likely to participate in the glucose homeostasis previously observed in response to these OT protocols. |
| Databáze: | OpenAIRE |
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