A study on the relationship of porphyria cutanea tarda and liver damage

Autor: Irene Horkay, P. Tamási, A. Prékopa, L. Dalmy, S. Dán
Rok vydání: 1973
Předmět:
Zdroj: Archiv f�r Dermatologische Forschung. 247:235-243
ISSN: 1432-069X
0340-3696
DOI: 10.1007/bf00596242
Popis: The relationship between porphyria and liver damage was studied in 24 cases with porphyria cutanea tarda treated with Ippen's cure. In the history of 22 patients an excessive alcohol ingestion, in that of 2 other patients permanent medication with antibaby pills could be demonstrated. Conclusions for the condition of the liver parenchyma were derived from the serum activities of mitochondrial GLDH and lysosomal arylsulfatase. The degree of the mesenchymal reaction of the liver was estimated by the quantitative assay of serum immunoglobulins. On the basis of the results a liver damage involving both the parenchyma and mesenchyma was proved in each patient. The immunoglobulogram showed a considerable resemblance to that of 16 patients with chronic alcoholic hepatopathy. The IgG and IgA values tendentiously decreased after a successful Ippen's cure. It is probable that the products of pathological porphyrin metabolism contribute to the aggravation of the chronic inflammatory liver process. Presumably the serial phlebotomies influence the activity of the mesenchymal reaction of the liver favourably by means of reducing its porphyrin and iron depot. It appears that valuable information can be obtained about the nature and course of the liver damage also in PCT by the help of immunoglobulin and enzymatic assays.
Databáze: OpenAIRE
Externí odkaz: