The effect of lithium treatment on manic symptoms and levels of monoamine metabolites in cerebrospinal fluid of manic depressive patients
| Autor: | U. Petterson, Göran Sedvall, Bengt Fyrö |
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| Rok vydání: | 1975 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Adolescent Lithium (medication) Lithium behavioral disciplines and activities chemistry.chemical_compound Cerebrospinal fluid Internal medicine mental disorders Humans Medicine Aged Phenylacetates Psychiatric Status Rating Scales Pharmacology Clinical Trials as Topic business.industry 5-Hydroxyindoleacetic acid Homovanillic acid Homovanillic Acid Hydroxyindoleacetic Acid Middle Aged Manic symptoms Manic depressive Lithium level Monoamine neurotransmitter Endocrinology nervous system chemistry Female business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Psychopharmacologia. 44:99-103 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00421192 |
| Popis: | Clinical effects, levels of 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) in cerebrospinal fluid (CSF) and lithium levels in serum were examined in 13 manic depressive patients acutely admitted because of a manic or hypomanic episode. Patients were examined before and 12 days after the beginning of lithium treatment. Manic scores were significantly reduced during treatment. The levels of 5-HIAA as well as HVA increased significantly during treatment. The HVA to 5-HIAA ratio was significantly reduced, indicating a more pronounced change in 5-HIAA than in HVA. The 5-HIAA and HVA levels before as well as after 12 days of treatment were significantly correlated. No significant correlation was found between manic scores and monoamine metabolites in CSF or between lithium level in serum and reduction of manic scores or elevation of monoamine metabolites in CSF in the relative small number of patients studied. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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