Anxiety and depression influence the relation between disability status and quality of life in multiple sclerosis
| Autor: | J. B. De Boer, F. G. A. Van Der Meche, P.A. van Doorn, Rogier Q. Hintzen, N. F. Kalkers, Jan Passchier, A. C. J. W. Janssens |
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| Přispěvatelé: | Neurology, Psychiatry |
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Activities of daily living Multiple Sclerosis Health Status Hospital Anxiety and Depression Scale 03 medical and health sciences Disability Evaluation 0302 clinical medicine Quality of life immune system diseases Activities of Daily Living medicine Humans 030212 general & internal medicine Psychiatry Depression (differential diagnoses) Depressive Disorder Expanded Disability Status Scale Middle Aged Mental health Anxiety Disorders nervous system diseases Neurology Cohort Quality of Life Anxiety Female Neurology (clinical) medicine.symptom Psychology 030217 neurology & neurosurgery |
| Zdroj: | Multiple Sclerosis, 9, 397-403. SAGE Publications Ltd |
| ISSN: | 1352-4585 |
| Popis: | Disability status, depression and anxiety are important determinants of quality of life (Q oL) in patients with multiple sclerosis (MS). We investigated whether anxiety and depression influence the relation between disability status and Q oL in our cohort of recently diagnosed patients. Disability status [Expanded Disability Status Scale (EDSS)], anxiety and depression [Hospital A nxiety and Depression Scale (HADS)], and Q oL (SF-36) were prospectively obtained in 101 MS patients. The relation between EDSS and SF-36 scales was examined using regression analyses, without and with adjustment for anxiety and depression. Interaction effects were investigated by comparing the relation between EDSS and Q oL in patients with high and low anxiety and depression. In the unadjusted analyses, EDSS was significantly related to all SF-36 physical and mental health scales. A fter adjustment for anxiety and depression, EDSS was significantly related only to the SF-36 physical functioning, role-physical functioning and bodily pain scales. The relation between EDSS and these SF-36 scales was consistently higher in patients with more symptoms of anxiety or depression, suggesting that anxiety and depression strengthened the association of EDSS in these SF-36 physical health scales. A fter adjustment for anxiety and depression, EDSS was not significantly related to the SF-36 mental health scales and the general health scale. This finding is compatible with the hypothesis that anxiety and depression are intermediate factors in the association of EDSS with these SF-36 scales. Screening for symptoms of anxiety and depression is recommended in studies that use Q oL as an outcome measure of treatment or intervention efficacy. |
| Databáze: | OpenAIRE |
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