MiR-455-3p, miR-150 and miR-375 are aberrantly expressed in salivary gland adenoid cystic carcinoma and polymorphous adenocarcinoma
| Autor: | Tuula Salo, Elizabeth Ferreira Martinez, Andresa Borges Soares, Ana Paula Dias Demasi, Lucas Novaes Teixeira, Amy Louise Brown, Marcelo Sperandio, Vera Cavalcanti de Araújo, Fabricio Passador-Santos, Ahmed Al-Samadi, Ilmo Leivo |
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| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
Adenoid cystic carcinoma Adenocarcinoma Salivary Glands Minor Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Mir-375 miR-150 microRNA medicine Humans Antibody-dependent cell-mediated cytotoxicity Salivary gland business.industry 030206 dentistry medicine.disease Salivary Gland Neoplasms Carcinoma Adenoid Cystic 3. Good health Salivary Gland Adenoid Cystic Carcinoma MicroRNAs medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Cancer research Periodontics Oral Surgery business |
| Zdroj: | Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyREFERENCES. 48(9) |
| ISSN: | 1600-0714 |
| Popis: | Adenoid cystic carcinoma (AdCC) and polymorphous adenocarcinoma (PAC) are included among the most common salivary gland cancers. They share clinical and histological characteristics, making their diagnosis challenging in specific cases. MicroRNAs (miRNA) are short, non-coding RNA sequences of 19-25 nucleotides in length that are involved in post-transcriptional protein expression. They have been shown to play important roles in neoplastic and non-neoplastic processes and have been suggested as diagnostic and prognostic markers.This study, using quantitative RT-PCR, investigated miR-150, miR-455-3p and miR-375 expression, in order to identify a possible molecular distinction between AdCC and PAC.miRNA-150 and miRNA-375 expression was significantly decreased in AdCC and PAC compared with salivary gland tissue controls, whilst miRNA-455-3p showed significantly increased expression in AdCC when compared to PAC, (P 0.05). miR-150, miR-357 and miR-455-3p expression in AdCC, PAC and control was not associated with age, gender nor with anatomic site (major and minor salivary glands) (P 0.05).MiR-455-3p could be used as a complimentary tool in the diagnosis of challenging AdCC cases. |
| Databáze: | OpenAIRE |
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