CSF nonphosphorylated Tau as a biomarker for the discrimination of AD from CJD

Autor:	Matthias Schmitz, Johannes Kornhuber, Piotr Lewczuk, Stefan Goebel, Peter Lange, Natalia Ermann, Franc Llorens, Inga Zerr, Tobias Knipper
Rok vydání:	2018
Předmět:	0301 basic medicine Pathology medicine.medical_specialty business.industry General Neuroscience Disease Brief Communication Epitope 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Cerebrospinal fluid Text mining mental disorders Medicine Biomarker (medicine) ddc:610 Neurology (clinical) Brief Communications business 030217 neurology & neurosurgery
Zdroj:	Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology 5(7), 883-887 (2018). doi:10.1002/acn3.584
ISSN:	2328-9503
DOI:	10.1002/acn3.584
Popis:	Creutzfeldt–Jakob disease and Alzheimer's disease are characterized by the presence of elevated total‐Tau cerebrospinal fluid concentrations while the presence of hyperphosphorylated Tau forms in the cerebrospinal fluid is rather a hallmark of Alzheimer's disease. Here we aimed to investigate potential contribution of nonphospho‐Tau epitopes (non‐P‐Tau) in the discrimination between both diseases. Non‐P‐Tau cerebrospinal fluid concentration was highly increased in Creutzfeldt–Jakob disease (n = 57, 3683 ± 3599 pg/mL) compared to Alzheimer's disease (n = 41, 148 ± 219 pg/mL) and neurological controls (n = 56, 62 ± 40 pg/mL), and significantly improved the proportion of correctly classified patients (99%) compared to that achieved by total‐Tau (90%), P‐Tau (62%) and 14‐3‐3 (91%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424373dd598dfa75a49d500ab7c1bade https://doi.org/10.1002/acn3.584 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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