Exercise chronotropy in patients with normal and impaired sinus node function after cardiac transplantation
Autor: | Christoph Kratochwill, Mighael Grimm, Gottfried Heinz, Susanne Radosztics, Gere Sunder-Plassmann, Heinz Gössinger, Gerhard Kreiner, Axel Lagzkovics, Peter Buxbaum, Günther Laufer |
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Rok vydání: | 1993 |
Předmět: |
Chronotropic
Heart transplantation Adult medicine.medical_specialty business.industry Arrhythmia sinus medicine.medical_treatment General Medicine Middle Aged Sinus node function Transplantation Heart Rate Internal medicine Heart rate Cardiology Exercise Test Medicine Heart Transplantation Humans In patient Arrhythmia Sinus Cardiology and Cardiovascular Medicine business Peak exercise |
Zdroj: | Pacing and clinical electrophysiology : PACE. 16(9) |
ISSN: | 0147-8389 |
Popis: | The chronotropic response during graded, symptom limited exercise was investigated in 32 cardiac transplant recipients a mean of 49 +/- 18 days after transplantation. All patients had systematic evaluation of postoperative donor sinus node (SN) function and the cardioacceleratory response was compared according to the SN function. Twenty-one patients had normal postoperative SN studies (corrected SN recovery time520 msec, group I) while the SN function was impaired postoperatively in the remainder (n = 11, group II; corrected SN recovery time 4,149 +/- 6,283 msec in 5 patients, junctional escape rhythm in 6 patients). All patients had regained sinus rhythm at time of the exercise test. Patients in group II had lower basal sinus rates at the beginning of exercise (91.5 +/- 11 vs 101.4 +/- 7 beats/min, P0.02). This lower chronotropy was maintained over every incremental step (F rate between groups = 30, P = 0.0001, F rate vs workload = 15, P = 0.0001 by two-way ANOVA) and resulted in a significantly lower heart rate at individual peak exercise (108.3 +/- 20 vs 124.2 +/- 13 beats/min, P0.02). A total of 14/16 patients in group I but only 2/16 patients in group II accomplished a peak heart rateor = 120 beats/min (P = 0.009). The workload achieved did not differ between the groups (107 +/- 29 vs 102 +/- 32 watts, P0.5). These data show a lower SN chronotropy during rest and at peak exercise in cardiac transplant recipients with postoperative SN deficiency and apparent normalization of SN function. |
Databáze: | OpenAIRE |
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