Activation of Coagulation by Heparin-Protamine Complexes as Demonstrated by Thrombotest
| Autor: | G. Gjengedal, H. C. Godal |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Time Factors
Pharmacology Neutralization In vivo medicine Humans Protamines Blood Coagulation Incubation biology Heparin Chemistry Heparin Antagonists Dextrans Hematology Blood Coagulation Disorders medicine.disease Thrombosis Protamine Coagulation Biochemistry Dextran sulphate biology.protein Blood Coagulation Tests Barium Sulfate Sulfonic Acids medicine.drug |
| Zdroj: | Scandinavian Journal of Haematology. 8:194-199 |
| ISSN: | 0036-553X |
| DOI: | 10.1111/j.1600-0609.1971.tb01973.x |
| Popis: | Coagulation activity, detectable by Thrombotest, is formed during incubation of blood or plasma with appropriate amounts of heparin and protamine or with heparin-like substances (dextran sulphate, Liquoid). The exact mechanism for this effect is not known, but in several respects it is similar to that obtained by contact with glass. The findings may be relevant to clinical observations such as increased risk of thrombosis following neutralization of heparin with protamine in vivo, and the so-called rebound effect of heparin. |
| Databáze: | OpenAIRE |
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