Human genes influence the interaction between Streptococcus mutans and host caries susceptibility: a genome-wide association study in children with primary dentition
| Autor: | Ying Meng, Jin Xiao, Tong Tong Wu, Dorota T Kopycka-Kedzierawski, Ronald J. Billings |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adolescent Dental Caries Susceptibility Genome-wide association study Dental Caries Genome informatics Microbiology Oral hygiene Article Streptococcus mutans Galactokinase 03 medical and health sciences 0302 clinical medicine Statistical significance Humans Medicine Tooth Deciduous Gene–environment interaction Child General Dentistry 2. Zero hunger biology Dentition DMF Index business.industry Host (biology) 030206 dentistry biology.organism_classification 3. Good health lcsh:RK1-715 030104 developmental biology Head start lcsh:Dentistry Immunology business Genome-Wide Association Study |
| Zdroj: | International Journal of Oral Science, Vol 11, Iss 2, Pp 1-8 (2019) International Journal of Oral Science |
| ISSN: | 2049-3169 1674-2818 |
| Popis: | Streptococcus mutans is a well-known cause of dental caries, due to its acidogenicity, aciduricity, and ability to synthesize exopolysaccharides in dental plaques. Intriguingly, not all children who carry S. mutans manifest caries, even with similar characteristics in oral hygiene, diet, and other environmental factors. This phenomenon suggests that host susceptibility potentially plays a role in the development of dental caries; however, the association between host genetics, S. mutans, and dental caries remains unclear. Therefore, this study examined the influence of host gene-by-S. mutans interaction on dental caries. Genome-wide association analyses were conducted in 709 US children ( |
| Databáze: | OpenAIRE |
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