Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma
| Autor: | Kunihisa Kobayashi, Midori Nakagawa, Hanako Ohishi, Kenji Ohe, Midori Minezaki, Hideyuki Fujii, Saori Takahara, Ichiro Abe, Makiko Abe, Tadachika Kudo, Toshihiko Yanase, Kaoru Sugimoto |
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| Rok vydání: | 2018 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Epinephrine Endocrinology Diabetes and Metabolism Adrenal Gland Neoplasms 030209 endocrinology & metabolism Pheochromocytoma Normetanephrine 03 medical and health sciences chemistry.chemical_compound Norepinephrine 0302 clinical medicine Endocrinology Insulin resistance Internal medicine Glucose Intolerance medicine Humans Metanephrine Glycemic Aged Glycated Hemoglobin business.industry Middle Aged medicine.disease Treatment Outcome chemistry 030220 oncology & carcinogenesis Female Glycated hemoglobin Insulin Resistance business hormones hormone substitutes and hormone antagonists Homeostasis medicine.drug |
| Zdroj: | Endocrine journal. 66(2) |
| ISSN: | 1348-4540 |
| Popis: | Glucose intolerance is often observed in patients with pheochromocytoma. However, it remains controversial issue that glucose intolerance on pheochromocytoma is caused by impaired insulin secretion and/or by increased insulin resistance. We aimed to reveal the mechanism of glucose intolerance on pheochromocytoma with regard to the type and amount of catecholamines released. We evaluated 12 individuals diagnosed with pheochromocytoma and who underwent surgery to remove it. We examined glycemic parameters before and after surgery and investigated the association between the change of parameters of insulin secretion (homeostasis model assessment of β-cell function (HOMA-β)), insulin resistance (homeostasis model assessment of insulin resistance (HOMA-IR)) and that of urinary levels of metanephrine/normetanephrine before and after surgery. Overall, fasting plasma glucose, glycated hemoglobin (HbA1c), HOMA-β, and HOMA-IR were improved significantly after surgery. Regression analysis showed that the improvement in HOMA-β from before to after surgery was significantly positively associated with an improvement in urinary levels of metanephrine from before to after surgery and showed a significantly negative association with improvement in urinary levels of normetanephrine from before to after surgery. The improvement in HOMA-IR from before to after surgery was significantly positively associated with an improvement in urinary levels of normetanephrine from before to after surgery. Our results showed that pheochromocytoma extirpation improved glycemic parameters. Furthermore, the different effects elicited by excess amounts of adrenaline and noradrenaline on glucose intolerance were demonstrated. |
| Databáze: | OpenAIRE |
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