Evaluation of Maternal Reproductive Outcomes and Biochemical Analysis from Wistar Audiogenic Rats (WAR) and Repercussions in Their Offspring

Autor: José Antônio Cortes de Oliveira, Gustavo Tadeu Volpato, Beatriz T Antunes, Eduardo H.L. Umeoka, Rafaianne Queiroz Moraes-Souza, Barshana Karki, Norberto Garcia-Cairasco, Yuri Karen Sinzato, Débora Cristina Damasceno
Přispěvatelé: Universidade Estadual Paulista (Unesp), Federal University of Mato Grosso (UFMT), University Center Unicerrado, Universidade de São Paulo (USP), Harvard Medical School
Rok vydání: 2020
Předmět:
Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
ISSN: 1933-7205
1933-7191
DOI: 10.1007/s43032-020-00236-0
Popis: Made available in DSpace on 2020-12-12T02:14:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 The objective of the present study was to evaluate maternal reproductive performance, body weight, and frequency of external and internal anomalies of newborns of Wistar Audiogenic Rat (WAR) females as compared with Wistar rats. The adult WAR and Wistar rats were mated within their respective strains. After confirming the pregnancy, the body weights were weekly evaluated. On day 21 of pregnancy, the female rats were anesthetized and sacrificed to evaluate the maternal reproductive outcomes and biochemical profile, newborn weight, and external and internal anomalies. The WAR strain gained less weight during the pregnancy and presented hyperproteinemia, hypertriglyceridemia, and embryonic losses concerning Wistar rats, suggesting an inadequate intrauterine condition for embryonic development and fetal viability. WAR also presented a higher percentage of newborns classified as small for gestational age related to intrauterine growth restriction, which was confirmed by the lower number of ossification centers. There was a higher percentage of skeletal anomalies compared with fetuses of the Wistar dams, confirming their greater susceptibility during the formation and development of their skeletal system. Thus, the WAR presents physiological alterations compromising the viability of their embryos and fetuses, leading to impaired development of the newborns. Tocogynecology Postgraduate Course Laboratory of Experimental Research on Gynecology and Obstetrics Botucatu Medical School São Paulo State University (UNESP) Laboratory of System Physiology and Reproductive Toxicology Institute of Biological and Health Sciences Federal University of Mato Grosso (UFMT) Faculty of Medicine University Center Unicerrado Neurosciences and Behavioral Sciences Department and Physiology Department Ribeirão Preto School of Medicine University of São Paulo Joslin Diabetes Center Harvard Medical School Departamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu - UNESP, Distrito de Rubião Júnior s/n Tocogynecology Postgraduate Course Laboratory of Experimental Research on Gynecology and Obstetrics Botucatu Medical School São Paulo State University (UNESP) Departamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu - UNESP, Distrito de Rubião Júnior s/n
Databáze: OpenAIRE
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