Prevalence and Utility of Low Mean Corpuscular Volume in Infants Admitted to the Neonatal Intensive Care Unit
| Autor: | Brandi Bell-Carey, Rupsa C. Boelig, Dana Neumann, Margaret A. Lafferty, Rose Guo, Caroline Edwards, Richard J. Derman, Jay S. Greenspan, Zubair H. Aghai |
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| Rok vydání: | 2020 |
| Předmět: |
Erythrocyte Indices
Male Pediatrics medicine.medical_specialty Neonatal intensive care unit Hemoglobins Abnormal Alpha-thalassemia Hemoglobin Barts 03 medical and health sciences 0302 clinical medicine Neonatal Screening alpha-Thalassemia Predictive Value of Tests Pregnancy 030225 pediatrics Intensive Care Units Neonatal medicine Humans 030212 general & internal medicine Mean corpuscular volume Retrospective Studies medicine.diagnostic_test business.industry Microcytosis Infant Newborn Complete blood count Normal mcv medicine.disease Case-Control Studies Pediatrics Perinatology and Child Health Female Iron status business circulatory and respiratory physiology |
| Zdroj: | The Journal of pediatrics. 227 |
| ISSN: | 1097-6833 |
| Popis: | To determine the prevalence of low mean corpuscular volume (MCV) in newborn infants admitted to the neonatal intensive care unit and to assess low MCV as a diagnostic test for alpha thalassemia.Retrospective analysis of all infants admitted to the neonatal intensive care unit between January 2010 and October 2018 for which a complete blood count was performed during the first 3 postnatal days. Infants with a low MCV were compared with those with a normal MCV. Infants with positive hemoglobin Bart (Hb Bart) were compared with those withnegative Hb Bart. Low MCV was also evaluated as a diagnostic test for alpha thalassemia.A total of 3851 infants (1386 preterm, 2465 term) met the inclusion criteria and 853 (22.2%) had a low MCV. A low MCV was more common in term (25%) compared with preterm infants (17.1%, P .001). Hb Bart positive newborn screening was identified in 133 infants (3.5%). Hb Bart was positive in 11.1% of infants with low MCV compared with 1.3% with normal MCV (P .001). The sensitivity, specificity, positive predictive value, and negative predictive value of low MCV for the diagnosis of alpha thalassemia were 71.4%, 79.6%, 11.3%, and 98.7%, respectively.As Hb Bart positive newborn screens were seen in only 11.1% of infants with microcytosis, further diagnostic investigation may be warranted in individual infants. Further research to correlate microcytosis with iron status in infants and mothers is needed as well as studies using DNA analysis for the evaluation of alpha thalassemia variants. |
| Databáze: | OpenAIRE |
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