A Systematic Review of Intervention Studies Examining Nutritional and Herbal Therapies for Mild Cognitive Impairment and Dementia Using Neuroimaging Methods: Study Characteristics and Intervention Efficacy
| Autor: | Nerida L Klupp, Dennis Hsu-Tung Chang, Genevieve Z. Steiner, Mark Hohenberg, Yong Huang, Danielle Mathersul, Freya MacMillan, David A. Camfield, Sai Wang Seto |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Blinding Psychological intervention Review Article Electroencephalography 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Neuroimaging Functional neuroimaging medicine Dementia Vascular dementia Psychiatry medicine.diagnostic_test business.industry Cognition lcsh:Other systems of medicine medicine.disease lcsh:RZ201-999 3. Good health 030104 developmental biology Complementary and alternative medicine business 030217 neurology & neurosurgery |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2017 (2017) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 |
| Popis: | Neuroimaging facilitates the assessment of complementary medicines (CMs) by providing a noninvasive insight into their mechanisms of action in the human brain. This is important for identifying the potential treatment options for target disease cohorts with complex pathophysiologies. The aim of this systematic review was to evaluate study characteristics, intervention efficacy, and the structural and functional neuroimaging methods used in research assessing nutritional and herbal medicines for mild cognitive impairment (MCI) and dementia. Six databases were searched for articles reporting on CMs, dementia, and neuroimaging methods. Data were extracted from 21/2,742 eligible full text articles and risk of bias was assessed. Nine studies examined people with Alzheimer’s disease, 7 MCI, 4 vascular dementia, and 1 all-cause dementia. Ten studies tested herbal medicines, 8 vitamins and supplements, and 3 nootropics. Ten studies used electroencephalography (EEG), 5 structural magnetic resonance imaging (MRI), 2 functional MRI (fMRI), 3 cerebral blood flow (CBF), 1 single photon emission tomography (SPECT), and 1 positron emission tomography (PET). Four studies had a low risk of bias, with the majority consistently demonstrating inadequate reporting on randomisation, allocation concealment, blinding, and power calculations. A narrative synthesis approach was assumed due to heterogeneity in study methods, interventions, target cohorts, and quality. Eleven key recommendations are suggested to advance future work in this area. |
| Databáze: | OpenAIRE |
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