Aqueous extract of Psoralea corylifolia L. inhibits lipopolysaccharide-induced endothelial-mesenchymal transition via downregulation of the NF-κB-SNAIL signaling pathway
| Autor: | Bom Jung, In Hye Cho, Jong Ho Kim, Eun Hyang Jang, Min-Ju Park, Darong Hong |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Lipopolysaccharides
Cancer Research Epithelial-Mesenchymal Transition Cell Down-Regulation Biology Psoralea Downregulation and upregulation Cell Movement Cell Line Tumor medicine Humans Epithelial–mesenchymal transition Cell Proliferation Cell growth Plant Extracts NF-kappa B Cell migration General Medicine Cell cycle Antineoplastic Agents Phytogenic Cell biology medicine.anatomical_structure Oncology embryonic structures Cancer cell Snail Family Transcription Factors Signal transduction Signal Transduction Transcription Factors |
| Zdroj: | Oncology reports. 34(4) |
| ISSN: | 1791-2431 |
| Popis: | The epithelial-mesenchymal transition (EMT) is a pivotal event in the invasion and metastasis of cancer cells. Psoralea corylifolia L. (PC) inhibits the proliferation of various cancer cells. However, its possible role in EMT has not been identified. In the present study, we examined the effects of an aqueous extract of Psoralea corylifolia L. (PCAE), a typical medicinal decoction, on the EMT. Lipopolysaccharide (LPS) induced EMT-like phenotypic changes, enhancing cell migration and invasion. However, PCAE markedly reduced the expression of the LPS-induced EMT markers, including N-cadherin and vimentin, and increased the expression of β-catenin. PCAE also inhibited cell migration and invasion in vitro. The effects of PCAE on the LPS-induced EMT were mediated by the inactivation of the NF-κB-SNAIL signaling pathway. The results provide new evidence that PCAE suppresses cancer cell invasion and migration by inhibiting EMT. Therefore, PCAE is a potentially effective dietary chemopreventive agent for malignant tumors since it inhibits metastasis. |
| Databáze: | OpenAIRE |
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