Renal 99mTc-DMSA pharmacokinetics in pediatric patients
| Autor: | Shannon O'Reilly, Justin L. Brown, Donika Plyku, Kitiwat Khamwan, S. Ted Treves, George Sgouros, Alison Goodkind, Frederic H. Fahey, Eric C. Frey, Ye Li, Briana Sexton-Stallone, Xinhua Cao, Wesley E. Bolch, David Zurakowski, Michael Ghaly |
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| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Pediatric imaging R895-920 Biomedical Engineering Prospective data 030218 nuclear medicine & medical imaging Medical physics. Medical radiology. Nuclear medicine 03 medical and health sciences DMSA 0302 clinical medicine Pharmacokinetics medicine Radiology Nuclear Medicine and imaging Instrumentation Pediatric nuclear medicine Radiation business.industry Compartmental modeling 99mTc-DMSA Patient data Pediatric patient Dose reduction/optimization 030220 oncology & carcinogenesis Radiological weapon business |
| Zdroj: | EJNMMI Physics, Vol 8, Iss 1, Pp 1-12 (2021) |
| ISSN: | 2197-7364 |
| DOI: | 10.1186/s40658-021-00401-7 |
| Popis: | Abstract 99mTc-DMSA is one of the most commonly used pediatric nuclear medicine imaging agents. Nevertheless, there are no pharmacokinetic (PK) models for 99mTc-DMSA in children, and currently available pediatric dose estimates for 99mTc-DMSA use pediatric S values with PK data derived from adults. Furthermore, the adult PK data were collected in the mid-70’s using quantification techniques and instrumentation available at the time. Using pediatric imaging data for DMSA, we have obtained kinetic parameters for DMSA that differ from those applicable to adults. Methods We obtained patient data from a retrospective re-evaluation of clinically collected pediatric SPECT images of 99mTc-DMSA in 54 pediatric patients from Boston’s Children Hospital (BCH), ranging in age from 1 to 16 years old. These were supplemented by prospective data from twenty-three pediatric patients (age range: 4 months to 6 years old). Results In pediatric patients, the plateau phase in fractional kidney uptake occurs at a fractional uptake value closer to 0.3 than the value of 0.5 reported by the International Commission on Radiological Protection (ICRP) for adult patients. This leads to a 27% lower time-integrated activity coefficient in pediatric patients than in adults. Over the age range examined, no age dependency in uptake fraction at the clinical imaging time was observed. Female pediatric patients had a 17% higher fractional kidney uptake at the clinical imaging time than males (P < 0.001). Conclusions Pediatric 99mTc-DMSA kinetics differ from those reported for adults and should be considered in pediatric patient dosimetry. Alternatively, the differences obtained in this study could reflect improved quantification methods and the need to re-examine DMSA kinetics in adults. |
| Databáze: | OpenAIRE |
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