Memory suppressor genes: Modulating acquisition, consolidation, and forgetting
| Autor: | Nathaniel C. Noyes, Ronald L. Davis, Anna Phan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Autism Spectrum Disorder
Nerve Tissue Proteins Article law.invention Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine law Memory Memory formation Animals Drosophila Proteins Humans Cyclic AMP Response Element-Binding Protein Gene 030304 developmental biology Memory Consolidation 0303 health sciences Forgetting Consolidation (soil) General Neuroscience Brain Limiting Receptors GABA-A Activating Transcription Factor 4 Repressor Proteins MicroRNAs Mental Recall Suppressor Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron |
| ISSN: | 1097-4199 |
| Popis: | The brain has a remarkable but underappreciated capacity to limit memory formation and expression. The term "memory suppressor gene" was coined in 1998 as an attempt to explain emerging reports that some genes appeared to limit memory. At that time, only a handful of memory suppressor genes were known, and they were understood to work by limiting cAMP-dependent consolidation. In the intervening decades, almost 100 memory suppressor genes with diverse functions have been discovered that affect not only consolidation but also acquisition and forgetting. Here we highlight the surprising extent to which biological limits are placed on memory formation through reviewing the literature on memory suppressor genes. In this review, we present memory suppressors within the framework of their actions on different memory operations: acquisition, consolidation, and forgetting. This is followed by a discussion of the reasons why there may be a biological need to limit memory formation. |
| Databáze: | OpenAIRE |
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