Effect of intravenous dexmedetomidine and remifentanil on neonatal outcomes after caesarean section under general anaesthesia
| Autor: | Cheol Joo Lee, Hyun Kang, Hyungtae Kim, Myeongjong Lee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cesarean Section
business.industry medicine.medical_treatment Infant Newborn Remifentanil Anesthesia General Anesthesiology and Pain Medicine Piperidines Pregnancy Anesthesia Meta-analysis medicine Clinical endpoint Humans Intubation Female Apgar score Caesarean section General anaesthesia Dexmedetomidine business medicine.drug |
| Zdroj: | European Journal of Anaesthesiology. 38:1085-1095 |
| ISSN: | 1365-2346 0265-0215 4201-9141 |
| Popis: | BACKGROUND Various strategies have been used to mitigate haemodynamic instability during general anaesthesia for caesarean section. However, the safety of these strategies for neonates remains controversial. OBJECTIVE To investigate the effects of intravenous dexmedetomidine and remifentanil on neonatal outcomes during caesarean section under general anaesthesia. DESIGN Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES Databases of PubMed, EMBASE and CENTRAL were searched until March 2020 and updated in February 2021. ELIGIBILITY CRITERIA Randomised controlled trials were included if they compared dexmedetomidine and remifentanil infusion on neonatal outcomes after elective caesarean section under general anaesthesia. Primary outcomes were 1 and 5 min Apgar scores. Secondary outcomes were the incidence of neonatal mask ventilation or endotracheal intubation, and pH of the umbilical artery and vein. Studies that did not report primary outcomes were excluded. RESULTS Five studies with 258 patients in total were included. The Apgar score at 1 min in the remifentanil group was lower than that in the dexmedetomidine group for both quantitative [weighted mean difference (WMD): 0.75; 95% CI, 0.44 to 1.07; τ2 = 0.00] and categorical outcomes (≥Apgar 7 vs. |
| Databáze: | OpenAIRE |
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