Investigation of Salmonella Phage–Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets
| Autor: | Ben Stamp, Avraam Tapinos, Nikolaos G. Papadopoulos, Elene Kakabadze, David Lee, Nina Chanishvili, Aidan Coffey, Ezra Herman, Spyridon Megremis, Khatuna Makalatia, David Robertson, Nata Bakuradze, Nino Grdzelishvili |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Salmonella Speciation viruses Network structure Network Generalist and specialist species medicine.disease_cause Nestedness Bacteriophages bacteria modularity Genetics biology Salmonella Phage Bacterial Infections QR1-502 Virus Anti-Bacterial Agents Infectious Diseases Salmonella enterica Salmonella Infections Infection Salmonella Phages bacteriophages Evolution nestedness salmonella 030106 microbiology Modularity virus Microbiology Article Host Specificity Evolution Molecular 03 medical and health sciences Virology evolution medicine Coevolution Bacteria Host Microbial Interactions biology.organism_classification infection 030104 developmental biology speciation network |
| Zdroj: | Viruses, Vol 13, Iss 1261, p 1261 (2021) Viruses Volume 13 Issue 7 Megremis, S 2021, ' Investigation of Salmonella Phage–Bacteria Infection Profiles: Network Structure Reveals a Gradient of Target-Range from Generalist to Specialist Phage Clones in Nested Subsets ', Viruses, vol. 13, no. 7, 1261 . https://doi.org/10.3390/v13071261, https://doi.org/10.3390/v13071261 |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v13071261 |
| Popis: | Bacteriophages that lyse Salmonella enterica are potential tools to target and control Salmonella infections. Investigating the host range of Salmonella phages is a key to understand their impact on bacterial ecology, coevolution and inform their use in intervention strategies. Virus–host infection networks have been used to characterize the “predator–prey” interactions between phages and bacteria and provide insights into host range and specificity. Here, we characterize the target-range and infection profiles of 13 Salmonella phage clones against a diverse set of 141 Salmonella strains. The environmental source and taxonomy contributed to the observed infection profiles, and genetically proximal phages shared similar infection profiles. Using in vitro infection data, we analyzed the structure of the Salmonella phage–bacteria infection network. The network has a non-random nested organization and weak modularity suggesting a gradient of target-range from generalist to specialist species with nested subsets, which are also observed within and across the different phage infection profile groups. Our results have implications for our understanding of the coevolutionary mechanisms shaping the ecological interactions between Salmonella phages and their bacterial hosts and can inform strategies for targeting Salmonella enterica with specific phage preparations. |
| Databáze: | OpenAIRE |
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