Obesity-associated severe asthma in an adult Japanese population
| Autor: | Yasuo To, Ichino Kano, Akihiro Hitani, Masako To, Kosuke Haruki, Natsue Honda, Yuta Kono |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Exacerbation Severity of Illness Index Cohort Studies 03 medical and health sciences FEV1/FVC ratio Sex Factors 0302 clinical medicine Japan Risk Factors Internal medicine Humans Medicine Obesity Risk factor Aged Retrospective Studies Asthma business.industry Retrospective cohort study Middle Aged medicine.disease respiratory tract diseases Logistic Models 030104 developmental biology 030228 respiratory system Cohort Disease Progression Female business Body mass index |
| Zdroj: | Respiratory Investigation. 56:440-447 |
| ISSN: | 2212-5345 |
| DOI: | 10.1016/j.resinv.2018.07.003 |
| Popis: | Background Severe asthma is increasingly being recognized as an important public health issue. Obesity has been identified as a risk factor for poor asthma control and for worsening of asthma severity. However, most studies investigating obese patients with asthma have been performed in Western countries. Reports on the characteristics of obese Japanese individuals with severe asthma are lacking. Herein, we investigated the clinical characteristics of patients with obesity-associated severe asthma in a Japanese population and the association between obesity and poor asthma control. Methods We conducted a retrospective observational study of adult patients with severe asthma. Patients were classified into two groups based on the definition of obesity recommended by the Japan Society for the Study of Obesity: obese (OB) group (body mass index [BMI] ≥25 kg/m2) and non-obese (NOB) group (BMI Results A total of 492 patients were enrolled. Age, smoking history in terms of number of pack-years, daily controller medications use, and spirometric data were not significantly different between the OB and NOB groups in either cohort. In the female cohort, the annual exacerbation ratio and the percentage of frequent exacerbators were significantly higher in the OB group compared to the NOB group. A multivariate logistic regression analysis showed that obesity was independently associated with frequent asthma exacerbations in the female cohort. Conclusions Our study revealed that obesity, defined as a BMI ≥25 kg/m2, was independently associated with poor asthma control (including acute exacerbations) in adult Japanese females with severe asthma. |
| Databáze: | OpenAIRE |
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