Selective separation of α- and β-cyclodextrins by complexation/ultrafiltration using supra molecular host-guest interaction
| Autor: | Nihel Ben Amar, André Deratani, Fatma Ellouze, Bastien Seantier |
|---|---|
| Přispěvatelé: | Multimedia, InfoRmation systems and Advanced Computing Laboratory (MIRACL), Faculté des Sciences Economiques et de Gestion de Sfax (FSEG Sfax), Université de Sfax - University of Sfax-Université de Sfax - University of Sfax, Institut de Recherche Dupuy de Lôme (IRDL), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne)-Centre National de la Recherche Scientifique (CNRS), Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM) |
| Rok vydání: | 2018 |
| Předmět: |
Steric effects
Molar Chemistry Ultrafiltration Membrane process Filtration and Separation 02 engineering and technology β cyclodextrins 010501 environmental sciences 021001 nanoscience & nanotechnology Host-guest inclusion complex 01 natural sciences Analytical Chemistry Solvent Membrane [CHIM]Chemical Sciences Physical chemistry Complexation-ultrafiltration Igepal Co-890 alpha-Cyclodextrin selective separation 0210 nano-technology Selectivity 0105 earth and related environmental sciences Bar (unit) |
| Zdroj: | Separation and Purification Technology Separation and Purification Technology, Elsevier, 2018, 204, pp.226-233. ⟨10.1016/j.seppur.2018.04.017⟩ |
| ISSN: | 1383-5866 |
| DOI: | 10.1016/j.seppur.2018.04.017 |
| Popis: | International audience; This work is aimed at developing a new process to separate alpha-cyclodextrin (CD) from binary alpha-CD/beta-CD mixtures. To achieve this objective, a membrane process was designed with water as solvent and using the selective accommodation of a guest Igepal Co-890 (IG) within the beta-CD cavity. In the first part, host-guest inclusion study suggested the formation of IG(2)/beta-CD complex in presence of IG excess. Moreover, increasing IG/CD molar ratio to 1.5 leads to the complete complexation of beta-CD while alpha-CD remains free. The second part was devoted to the separation of alpha- and beta-CD using UF membranes (GH and GK from GE-Osmonics). The influence of parameters including membrane molecular weight cut-off (MWCO), transmembrane pressure (Delta P), IG/beta-CD and alpha-CD/beta-CD molar ratios, was investigated. MWCO, Delta P, IG/beta-CD and alpha-CD/beta-CD molar ratios respectively of 1000 Da, 2 bar, 1.5 and 11:89 are the optimized values to reach an alpha-CD separation factor as high as 38. The experimental data fits very well with predicted values calculated using the parameters found in the complexation study and rejection of single solutions indicating that selectivity predominantly originates from steric exclusion of species by membrane GH. |
| Databáze: | OpenAIRE |
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