Personalized prescription of imatinib in recurrent granulosa cell tumor of the ovary: case report
| Autor: | Elena Poddubskaya, Alexey Aleshin, Lyudmila Makovskaia, Daria Allina, Maria Suntsova, Irina N. Kochergina-Nikitskaya, Marina Sekacheva, Viktoria Barbara, Madina Baranova, Dmitriy E. Kamashev |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Research Report Oncology medicine.medical_specialty Granulosa cell Salvage therapy Ovary Disease ovarian neoplasm Internal medicine medicine Humans Precision Medicine Medical prescription Granulosa Cell Tumor business.industry Imatinib General Medicine medicine.disease Gynecological cancer Treatment Outcome medicine.anatomical_structure Imatinib Mesylate Female Neoplasm Recurrence Local Ovarian cancer business medicine.drug |
| Zdroj: | Cold Spring Harbor Molecular Case Studies |
| ISSN: | 2373-2873 2373-2865 |
| DOI: | 10.1101/mcs.a003434 |
| Popis: | Ovarian cancer is the fifth leading cause of cancer-related female mortality and the most lethal gynecological cancer. In this report, we present a rare case of recurrent granulosa cell tumor (GCT) of the ovary. We describe the case of a 26-yr-old woman with progressive GCT of the right ovary despite multiple lines of therapy who underwent salvage therapy selection based on a novel bioinformatical decision support tool (Oncobox). This analysis generated a list of potentially actionable compounds, which when used clinically lead to partial response and later long-term stabilization of the patient's disease. |
| Databáze: | OpenAIRE |
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