Dysphagia in amyotrophic lateral sclerosis: prevalence and clinical findings

Autor:	Luca Prosperini, Ilenia Schettino, Vincenzo Silani, Vittorio Frasca, Rocco Roma, Antonio Greco, C. Cambieri, Patrizia Mancini, Elena Giacomelli, Maurizio Inghilleri, M. De Vincentiis, Giovanni Ruoppolo
Rok vydání:	2013
Předmět:	Adult Male medicine.medical_specialty Oral swallowing Cough reflex amyotrophic lateral sclerosis cough reflex dysphagia deglutition disorders Severity of Illness Index Statistics Nonparametric stomatognathic system Swallowing Predictive Value of Tests otorhinolaryngologic diseases medicine Prevalence Humans In patient Amyotrophic lateral sclerosis Aged Retrospective Studies Aged 80 and over business.industry digestive oral and skin physiology Amyotrophic Lateral Sclerosis General Medicine Middle Aged medicine.disease Dysphagia Logistic Models Neurology Anesthesia Physical therapy Bulbar onset Functional status Female Neurology (clinical) medicine.symptom business Deglutition Disorders Follow-Up Studies
Zdroj:	Acta neurologica Scandinavica. 128(6)
ISSN:	1600-0404
Popis:	Objectives To characterize swallowing deficits in amyotrophic lateral sclerosis (ALS); investigate the delay in dysphagia onset; estimate correlations between dysphagia severity and patients' functional status; identify the symptom(s) most likely to predict dysphagia. Materials and methods A group of 49 consecutive patients with ALS, 14 with bulbar onset and 35 with spinal onset, underwent swallowing evaluation including bedside and fiberoptic endoscopic examination to detect dysphagia. Results Patients with dysphagia were more likely than those without to have bulbar onset ALS (P = 0.02); more severely impaired chewing (P = 0.01); and tongue muscle deficits (P = 0.001). The only variable measured at first examination significantly associated with dysphagia was a more than mild tongue muscle deficit. The only variable useful in predicting dysphagia was a chewing deficit. In 10 of the 49 patients studied, swallowing evaluation disclosed an impaired cough reflex. Conclusions Dysphagia in patients with ALS correlates significantly with bulbar onset and with oral swallowing impairment. Fiberoptic swallowing evaluation is a useful tool for detecting swallowing deficits and laryngeal sensitivity in patients with ALS. An impaired cough reflex is an unexpected finding in many patients with ALS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42330904d081c0ccd0e8c7c1dd707940 https://pubmed.ncbi.nlm.nih.gov/23668293 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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