Heart-Ankle Pulse Wave Velocity Is Superior to Brachial-Ankle Pulse Wave Velocity in Detecting Aldosterone-Induced Arterial Stiffness
| Autor: | Chen, Zheng-Wei, Pan, Chien-Ting, Tsai, Cheng-Hsuan, Chang, Yi-Yao, Chang, Chin-Chen, Lee, Bo-Ching, Chiu, Yu-Wei, Huang, Wei-Chieh, Lin, Yu-Li, Wu, Vin-Cent, Hung, Chi-Sheng, Liao, Che-Wei, Lin, Yen-Hung, Group, on behalf of TAIPAI Study Group on behalf of TAIPAI Study |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
QH301-705.5 Medicine (miscellaneous) brachial-ankle pulse wave velocity heart-ankle pulse wave velocity Essential hypertension General Biochemistry Genetics and Molecular Biology Article chemistry.chemical_compound Primary aldosteronism Internal medicine medicine cardiovascular diseases Biology (General) Pulse wave velocity Aldosterone primary aldosteronism Receiver operating characteristic business.industry Wave velocity medicine.disease Blood pressure arterial stiffness chemistry Arterial stiffness Cardiology cardiovascular system business circulatory and respiratory physiology |
| Zdroj: | Biomedicines Volume 9 Issue 10 Biomedicines, Vol 9, Iss 1285, p 1285 (2021) |
| ISSN: | 2227-9059 |
| Popis: | Primary aldosteronism (PA) is associated with higher arterial stiffness compared to essential hypertension (EH). However, few studies have compared different pulse wave velocity (PWV) parameters to detect aldosterone-induced arterial stiffness. In this study, we aimed to compare the sensitivity in detecting aldosterone-induced arterial stiffness between brachial-ankle PWV (baPWV) and heart-ankle PWV (haPWV). We prospectively enrolled 1006 PA patients and 983 EH patients. Detailed medical history, basic biochemistry data and two PWV measurements (baPWV and haPWV) were collected in both groups. We performed analysis on the original cohort and two propensity score matching (PSM) models (model 1 adjusted for age and sex model 2 adjusted for age, sex, systolic and diastolic blood pressure). The DeLong test was used to compare areas under receiver operating characteristic curves (AUCs) between baPWV and haPWV to predict PA. In all models, the PA patients had significantly higher baPWV compared to the EH patients. The AUC of haPWV was greater than that of baPWV. In conclusion, haPWV seems to be a better PWV parameter than baPWV in detecting aldosterone-induced arterial stiffness. |
| Databáze: | OpenAIRE |
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