Dual anti-inflammatory and anti-parasitic action of topical ivermectin 1% in papulopustular rosacea
| Autor: | Lena Gonser, Martin Schaller, Katharina Belge, Alexander Scheu, Claudia Borelli, Renate Nordin, Christina Braunsdorf |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Administration Topical Anti-Inflammatory Agents Pilot Projects Dermatology Anti-inflammatory 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Ivermectin Papulopustular In vivo parasitic diseases medicine Papulopustular rosacea Animals Humans Mode of action Aged Mites biology Antiparasitic Agents business.industry Middle Aged medicine.disease biology.organism_classification Infectious Diseases Rosacea 030220 oncology & carcinogenesis Female business Demodex medicine.drug |
| Zdroj: | Journal of the European Academy of Dermatology and Venereology : JEADV. 31(11) |
| ISSN: | 1468-3083 |
| Popis: | Background Recently, therapy of rosacea with inflammatory lesions (papulopustular) has improved substantially with the approval of topical ivermectin 1% cream. It is assumed to have a dual mode of action with anti-inflammatory capacities and anti-parasitic effect against Demodex, which however has not yet been demonstrated in vivo. Aim To find scientific rationale for the dual anti-inflammatory and anti-parasitic mode of action of topical ivermectin 1% cream in patients with rosacea. Methods A monocentric pilot study was performed including 20 Caucasian patients with moderate to severe rosacea, as assessed by investigator global assessment (IGA score ≥ 3) and a demodex density ≥ 15/cm2. Patients were treated with topical ivermectin 1% cream once daily (Soolantra®) for ≥12 weeks. The density of Demodex mites was assessed with skin surface biopsies. Expression of inflammatory and immune markers were evaluated with RT-PCR and by immunofluorescence staining. Results The mean density of mites was significantly decreased at week 6 and week 12 (p |
| Databáze: | OpenAIRE |
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