Binding and segregation of proteins in membrane adhesion: Theory, modelling, and simulations
| Autor: | Weikl, T., Hu, J., Kav, B., Różycki, B. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Advances in Biomembranes and Lipid Self-Assembly Multiresponsive Behavior of Biomembranes and Giant Vesicles |
| Popis: | The adhesion of biomembranes is mediated by the binding of membrane-anchored receptor and ligand proteins. The proteins can only bind if the separation between apposing membranes is sufficiently close to the length of the protein complexes, which leads to an interplay between protein binding and membrane shape. In this article, we review current models of biomembrane adhesion and novel insights obtained from the models. Theory and simulations with elastic-membrane and coarse-grained molecular models of biomembrane adhesion indicate that the binding of proteins in membrane adhesion strongly depends on nanoscale shape fluctuations of the apposing membranes, which results in binding cooperativity. A length mismatch between protein complexes leads to repulsive interactions that are caused by membrane bending and act as a driving force for the length-based segregation of proteins during membrane adhesion. Review article with 39 pages and 11 figures in "Advances in Biomembranes and Lipid Self-Assembly", Volume 30 (2019) |
| Databáze: | OpenAIRE |
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