Crosstalk between cytokine profile, redox, and iron status in β-Thalassemia: relation to frequency/duration of blood transfusion

Autor:	Walaa A. Keshk, Noha E. Esheba, Nahed Mohammed Hablas, Shereen Awny Abd Elsalam
Rok vydání:	2019
Předmět:	Male Blood transfusion Adolescent medicine.medical_treatment Thalassemia Lymphocyte Iron Physiology Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Medicine Humans Blood Transfusion Child Interleukin 4 biology business.industry beta-Thalassemia Hematology medicine.disease Ferritin Interleukin 10 medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health Interleukin 13 biology.protein Cytokines Female business Oxidation-Reduction 030215 immunology
Zdroj:	Pediatric hematology and oncology. 36(3)
ISSN:	1521-0669
Popis:	β-Thalassemia, a blood disease instigated by mutations in β-globin genes or their regulatory regions. Infectious complications, immune abnormalities and iron overload related organ damage are the chief causes of morbidity and mortality. The role of inflammatory cytokines in the pathophysiology of β-thalassemia is still indistinct, so the present study aimed to evaluate immune-inflammatory and redox status in β-thalassemia and their relation to iron status, frequency/duration of blood transfusion. Seventy β-Thalassemia patients (35 β-thalassemia major; 35 β-thalassemia intermedia) and twenty age and sex-matched healthy controls were included. Interleukin4 (IL4), Interleukin10 (IL10), Interleukin 8 (IL8), and Interleukin 13 (IL13) levels were immunoassayed in addition to iron, hematological and redox status assessment. Significantly increased iron, ferritin, IL8, IL13 levels (p value ˂0.001), meanwhile, decreased IL10 level, total anti-oxidant (TAC) and iron binding capacities were observed in β-thalassemia major compared with β-thalassemia intermedia and control groups (p value ˂0.001) . IL4 level was decreased in patients group compared to control. Positive correlation was found between malondialdehyde (MDA), IL8, IL13 and iron load, transfusion frequency/duration, total leucocyte count and lymphocyte (%). Meanwhile, negative correlation was found with IL4, IL10, and TAC. Multiple blood transfusions increased iron stores which may critically impair the immune-regulatory balance with disturbed redox status and cytokine profile.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422c8dde2d76e8fc4eb55c7eac18777d https://pubmed.ncbi.nlm.nih.gov/31032672 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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